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Image Search Results
Journal: Frontiers in Cellular Neuroscience
Article Title: Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles
doi: 10.3389/fncel.2024.1334244
Figure Lengend Snippet: Single nuclei Multiome analysis of the MGE Ezh2 cKO mice. (A) UMAP plots of E12.5 and E15.5 integrated single nuclei RNA- and ATAC-seq (Multiome) dataset via weighted nearest neighbor (WNN), annotated by age and genotype (left and middle) or putative cell clusters (right). Labels for putative cell clusters are listed above the UMAP. (B) Integrated E12.5+E15.5 RNA and ATAC dataset annotated by genotype (left) and age (right). (C) Markers for radial glia cells ( Nes ), cycling GE progenitors ( Ascl1 ) and post-mitotic immature neurons ( Dcx , Rbfox3 ), with general trajectory confirmed by pseudotime in the integrated E12.5+E15.5 UMAP plot.
Article Snippet: We generated single nuclei suspensions from E12.5 and E15.5 MGE and used the
Techniques: